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Comparative performance of AnTicoagulation and Risk factors In Atrial fibrillation and Global Registry of Acute Coronary Events risk scores in predicting long-term adverse events in patients with acute myocardial infarction [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(2): 77-84 | DOI: 10.14744/AnatolJCardiol.2018.54815  

Comparative performance of AnTicoagulation and Risk factors In Atrial fibrillation and Global Registry of Acute Coronary Events risk scores in predicting long-term adverse events in patients with acute myocardial infarction

Gökhan Çetinkal1, Cüneyt Koçaş2, Betül Balaban Kocaş1, Şükrü Arslan2, Okay Abacı2, Osman Şükrü Karaca2, Yalçın Dalgıç2, Özgür Selim Ser2, Kudret Keskin1, Ahmet Yıldız2, Sait Mesut Dogan2
1Department of Cardiology, Şişli Hamidiye Etfal Training and Research Hospital; İstanbul-Turkey
2Department of Cardiology, İstanbul University Institute of Cardiology; İstanbul-Turkey

Objective: This study is designed to evaluate the recently developed AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) risk score (RS), which determines the predisposition to thromboembolic and hemorrhagic events in atrial fibrillation, as a predictor of prognosis in patients having acute myocardial infarction (AMI), and to compare the predictive ability of ATRIA RS with GRACE RS.
Methods: We analyzed 1627 patients having AMI who underwent coronary angiography and/or percutaneous coronary intervention (PCI) between January 2011 and February 2015. The primary endpoints included all-cause mortality, non-fatal MI, and cerebrovascular events during follow-up.
Results: Multivariate Cox regression analysis showed that the ATRIA RS>3 was an independent predictor of major adverse cardiac events in patients with AMI [hazard ratio, 2.00, 95% confidence interval, 1.54 to 2.60, p<0,001]. The area under the curve (AUC) for ATRIA RS and GRACE RS was 0.66 and 0.67 (p<0.001, and p<0.001), respectively. We performed a pair-wise comparison of receiver operating characteristic curves,and noted the predictive value of ATRIA RS with regard to primary endpoints was similar to that of GRACE RS (By DeLong method, AUCATRIA vs. AUCGRACE z test=0.64, p=0.52).
Conclusion: ATRIA RS may be useful in predicting prognosis in patients having AMI during long-term follow-up.

Keywords: ATRIA risk score, acute myocardial infarction, risk stratification


Gökhan Çetinkal, Cüneyt Koçaş, Betül Balaban Kocaş, Şükrü Arslan, Okay Abacı, Osman Şükrü Karaca, Yalçın Dalgıç, Özgür Selim Ser, Kudret Keskin, Ahmet Yıldız, Sait Mesut Dogan. Comparative performance of AnTicoagulation and Risk factors In Atrial fibrillation and Global Registry of Acute Coronary Events risk scores in predicting long-term adverse events in patients with acute myocardial infarction. Anatol J Cardiol. 2018; 20(2): 77-84

Corresponding Author: Gökhan Çetinkal, Türkiye


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