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Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(2): 131-136 | DOI: 10.14744/AnatolJCardiol.2017.8081  

Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque

Nilgün Çekin1, Arzu Özcan1, Sabahattin Göksel2, Serdal Arslan1, Ergün Pınarbaşı1, Öcal Berkan2
1Department of Medical Biology, Faculty of Medicine, Cumhuriyet University; Sivas-Turkey
2Department of Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University; Sivas-Turkey

Objective: Cardiovascular diseases are the most important cause of mortality worldwide, particularly atherosclerosis. Recently, lncRNAs affecting atherosclerotic progression have been reported in vascular smooth muscle cells, endothelial cells, and monocytes, suggesting that lncRNAs play an important role in atherosclerosis.
Methods: In recent clinical studies, nowadays, it was determined that internal mammary bypass grafts are closest to ideal grafts in coronary artery bypass surgery. In this study, we used tissue samples taken from atherosclerotic coronary arteries and the internal mammary artery (IMA) during coronary artery bypass surgery. Using RT-PCR, we investigated the role of two lncRNAs, FENDRR and LincRNA-p21, by comparing their expression levels in coronary artery plaques and normal mammary arteries of 20 atherosclerotic patients.
Results: We found that the FENDRR and LincRNA-p21 expressions decreased by approximately 2 and 7 fold in coronary artery plaques, respectively, compared with those in IMA, which is known to have no plaque development.
Conclusion: This study was the first to use mammary artery tissues of the same patients as a control and to study FENDRR expression. Our data may provide helpful insights regarding the association of lncRNAs and atherosclerosis.

Keywords: atherosclerosis, lncRNA, FENDRR, lincRNA-p21, coronary artery plaque, internal mammary arteries


Nilgün Çekin, Arzu Özcan, Sabahattin Göksel, Serdal Arslan, Ergün Pınarbaşı, Öcal Berkan. Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque. Anatol J Cardiol. 2018; 19(2): 131-136

Corresponding Author: Nilgün Çekin, Türkiye


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