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B antigen of blood type is associated with worse NYHA classification in male patients with hypertrophic cardiomyopathy [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-40607 | DOI: 10.14744/AnatolJCardiol.2018.40607  

B antigen of blood type is associated with worse NYHA classification in male patients with hypertrophic cardiomyopathy

Xiaowei Jiang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Hongwei Tian, Shubin Qiao
Department of cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,China

Objective: ABO blood group is associated with cardiovascular diseases. Several studies have suggested sex-related differences in both HCM clinical features and ABO blood type. However, few data are available regarding ABO blood type to clinical features of hypertrophic cardiomyopathy (HCM). We aimed to analyze the differences between ABO group and HCM and the potential effects of sex on these differences.
Methods: A total of 549 HCM patients were enrolled consecutively. Left ventricular outflow tract gradients at rest (LOVTG-R) were measured by Echocardiography. Left ventricular end-diastolic dimension (LVEDD), interventricular septum (IVS), left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and left ventricular mass (LVM) were assessed with cardiovascular magnetic resonance imaging (CMRI). Results: Compared with non-B antigen group, patients with B antigen had significantly higher LOVTG-R and LVEF, worse NYHA classification, lower left ventricular volume index, and no different in left ventricular mass index. After beings adjusted with sex, male patients with B antigen still had higher levels of LOVTG-R and frequency of NYHA classification III/IV, lower levels of LVEDV index and LVESV index. These differences were all lost in female patients. Also patients with NYHA classification III/IV had lower LVEDV index.
Conclusions: In male, not female, HCM patients with blood group B antigens has trended to worse cardiac functional capacity, higher LOVTG-R, and smaller left ventricular volume index. These relationships could be a potential indicator for clinical prevention. We speculate that rehydration may be more efficient to relieve symptoms in male HCM patients with B antigens

Keywords: Hypertrophic cardiomyopathy, ABO blood type, Sex

Corresponding Author: Shubin Qiao, China

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